Forensic Context

A study in humans demonstrated that miR-29a-3p is markedly upregulated in trauma patient plasma and possesses strong diagnostic and predictive abilities for overall trauma severity, organ injury, coagulation, endothelial activation, and inflammation, with a cross-validated AUROC of 0.98 for distinguishing trauma from healthy controls [Ren et al. DOI:10.1016/j.isci.2025.113569]. In murine lung alveolar epithelial cells, miR-29a-3p was downregulated following paraquat-induced injury and its target genes are involved in DNA methylation and apoptosis pathways [Zhao et al. DOI:10.2131/Jts.45.423]. In human plasma, the miR-29a-3p was significantly upregulated in patients with Adult-onset Still’s disease compared to healthy controls and sepsis patients, forming part of a validated diagnostic panel with an AUC of 0.8250 [Hu et al. DOI:10.3389/fimmu.2018.03099].