Basic Information

Symbol
hsa-mir-29b-1
RNA class
miRNA miRNA hairpin
Alias
MIR29B1 MicroRNA 29b-1 Hsa-MiR-29b-1-5p Hsa-MiR-29b-3p Hsa-Mir-29b-1 MIRN29B1 Hsa-Mir-29-P1b-V1_pre Hsa-Mir-29-P1b-V2_pre MIMAT0004514 MIMAT0000100 MiRNA29B1 Mir-29b-1 MI0000105 MiR-29b hsa-mir-29b
Location (GRCh38)
7:130877459-130877539
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden death from CNS diseases Forensic psychiatry evaluation Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-29b-1
Sequence length
81 nt
GC content
0.3951

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.10 kcal/mol
Thermodynamic ensemble
Free energy: -35.52 kcal/mol
Frequency: 0.1002
Diversity: 6.28
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((((((((((((.((((((..((((((.............)))))))))))).)))))))))).))))))))).
Thermodynamic Ensemble Prediction
(((((((({((((((((((.((((((..,(((((..........,..)))))})))))).)))))))))).})))))))).
Forensic Context

A study in mice demonstrated that ethanol exposure suppresses the mir-29b-1 in developing cerebellar granule neurons, inducing apoptosis, while its overexpression protects against ethanol-induced neuronal death by regulating the SP1/RAX/PKR cascade [Qi et al. DOI:10.1074/Jbc.M113.535195]. In human cardiac stromal cells, the mir-29b-1 was significantly upregulated in arrhythmogenic cardiomyopathy patients, with its target genes enriched in extracellular matrix organization pathways [Rainer et al. DOI:10.1186/s12864-018-4876-6]. In human studies, the mir-29b-1 is upregulated in the anterior cingulate gyri of Parkinson's disease patients and downregulated in their blood, associating it with disease pathology [Das et al. DOI:10.1080/21655979.2021.2003667].