Forensic Context

A study in human cardiac stromal cells demonstrated that the miR-29b-3p was significantly upregulated in arrhythmogenic cardiomyopathy (ACM) patients compared to healthy controls, with its target genes involved in extracellular matrix organization [Rainer et al. DOI:10.1186/s12864-018-4876-6]. In human skin, research found the miR-29b-3p was downregulated five days post-burn in deep partial thickness burn skin compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A review consolidating knowledge across human, rat, mouse, and rabbit models notes the miR-29b-3p affects collagen gene expression to improve extracellular matrix remodeling during tissue repair, and a miR-29b mimic (Remlarsen) has advanced to clinical trials for wound healing [Badanina et al. DOI:10.3390/ijms262010060].