Basic Information

Symbol
hsa-mir-296
RNA class
miRNA miRNA hairpin
Alias
MIR296 MicroRNA 296 Hsa-MiR-296-3p Hsa-MiR-296-5p Hsa-Mir-296 MIRN296 Hsa-Mir-296_pre MIMAT0000690 MIMAT0004679 MI0000747 MiRNA296 Mir-296
Location (GRCh38)
20:58817615-58817694
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Tissue/body fluid identification Wound age identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-296
Sequence length
80 nt
GC content
0.6000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.00 kcal/mol
Thermodynamic ensemble
Free energy: -42.56 kcal/mol
Frequency: 0.0791
Diversity: 9.91
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((((..(((((((.((.(((((((((.(((.........)))))))))))).)).)))))))..)))))).)))
Thermodynamic Ensemble Prediction
.(({((((((..(((((((.((,(((((((((.({(.........}),))))))))).)).)))))))..)))))).))}
Forensic Context

A study in humans demonstrated that the mir-296 was significantly upregulated (3.82-fold) in exosomal miRNA from postmortem serum of acute myocardial infarction cases compared to hemorrhagic shock controls, indicating its potential association with this pathology [Kanno et al. DOI:10.1007/S00414-022-02913-Y]. In a separate human study, a candidate miRNA marker for menstrual blood identification, selected from microarray screening, was not confirmed by subsequent RT-PCR validation, which showed non-specific expression across all tested body fluids [Zubakov et al. DOI:10.1007/s00414-009-0402-3]. A study in mice demonstrated that the mir-296 is up-regulated in wound tissue during skin wound healing [Wang et al. DOI:10.1016/j.ajpath.2012.08.022], and a review of traumatic brain injury (TBI) research noted that the mir-296 is up-regulated in mouse brain tissue biopsy following mild TBI and was mentioned as an angiogenic factor in wound healing contexts [Martinez & Peplow DOI:10.4103/1673-5374.219025].