Basic Information

Symbol
hsa-mir-298
RNA class
miRNA miRNA hairpin
Alias
MIR298 MicroRNA 298 Hsa-Mir-298 Hsa-MiR-298 MIRN298 MIMAT0004901 MI0005523
Location (GRCh38)
X:146027794-146027872
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-298
Sequence length
88 nt
GC content
0.5341

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.10 kcal/mol
Thermodynamic ensemble
Free energy: -35.92 kcal/mol
Frequency: 0.7435
Diversity: 0.79
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((..((((.((((((((((((..((((((.(((((.(.......).)))).).))))))..))))))..)))))).)))).)))...
Thermodynamic Ensemble Prediction
(((..((((.((((((((((((..(((((({,((((,(....,,.,.)))).)}))))))..))))))..)))))).)))).)))...
Forensic Context

A review of human skin burns, wound healing, and scarring identified 197 miRNAs with altered expression, including the mir-298 which was upregulated in deep partial thickness burn skin four days post-injury compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-298 is reduced in brains of Alzheimer's disease transgenic animals and is associated with higher BACE1 protein levels, indicating its involvement in translational control of BACE1 [Wang et al. DOI:10.1101/Lm.026492.112]. This biomarker is also identified as being altered in AD pathology in human and rodent models [Das et al. DOI:10.1080/21655979.2021.2003667].