Basic Information
Symbol
hsa-miR-298
RNA class
miRNA
mature miRNA
Alias
hsa-miR-298
MIR298
MicroRNA 298
Location (GRCh38)
-
Forensic tag(s)
Wound age identification
Forensic psychiatry evaluation
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.10 kcal/mol
Thermodynamic ensemble
Free energy:
-35.92 kcal/mol
Frequency:
0.7435
Diversity:
0.79
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((..((((.((((((((((((..((((((.(((((.(.......).)))).).))))))..))))))..)))))).)))).)))...
Thermodynamic Ensemble Prediction
(((..((((.((((((((((((..(((((({,((((,(....,,.,.)))).)}))))))..))))))..)))))).)))).)))...
Forensic Context
A review of human skin burns, wound healing, and scarring identified 197 miRNAs with altered expression, including the miR-298 which was upregulated in deep partial thickness burn skin four days post-injury compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the miR-298 is reduced in brains of Alzheimer's disease transgenic animals and is associated with higher BACE1 protein levels, indicating its involvement in translational control of BACE1 [Wang et al. DOI:10.1101/Lm.026492.112]. This biomarker is also identified as being altered in AD pathology in human and rodent models [Das et al. DOI:10.1080/21655979.2021.2003667].