Basic Information

Symbol
hsa-mir-30a
RNA class
miRNA miRNA hairpin
Alias
MIR30A MicroRNA 30a Hsa-MiR-30a-3p Hsa-MiR-30a-5p Hsa-Mir-30a MIRN30A Hsa-Mir-30-P1b_pre MIMAT0000087 MIMAT0000088 MI0000088 Mir-30a
Location (GRCh38)
19:53721076-53721142
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-30a
Sequence length
71 nt
GC content
0.5352

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-37.20 kcal/mol
Thermodynamic ensemble
Free energy: -38.03 kcal/mol
Frequency: 0.2613
Diversity: 3.27
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((.((((((((((((..((((((((((((((....)))}....,)))))))))))))))))))))).)))
Forensic Context

A study in humans demonstrated that the mir-30a was significantly positively correlated with age in peripheral blood from physiologically unaffected individuals, showing a correlation of 0.429 with a raw P value of 1.58E-05 in a microarray analysis [Meder et al. DOI:10.1373/clinchem.2014.224238]. In a separate human study, the mir-30a was identified as up-regulated in plasma from young patients with ST-segment elevation myocardial infarction (STEMI) via small RNA sequencing, though it was not validated by subsequent qRT-PCR [Tong et al. DOI:10.3390/ijms19051467]. A study in Göttingen minipigs (Sus scrofa domestica) demonstrated that the mir-30a was identified as a cnvd-miRNA with sequence homology to humans, though it had not previously been linked to the minipig radiation model [Chakraborty et al. DOI:10.1038/s41598-023-45250-9]. A review of male infertility research indicated that a mimic of the mir-30a exhibits antioxidant and anti-apoptotic properties, protecting spermatogonial stem cells during cryopreservation [Doghish et al. DOI:10.1007/s00210-024-03594-7].