Forensic Context

A study in mice demonstrated that the miR-30a-3p is a serum microRNA that distinguishes sublethal from lethal total body irradiation doses and correlates with survival outcomes, with its levels shifting in response to radioprotective or mitigative interventions [Acharya et al. DOI:10.1126/scitranslmed.aaa6593]. In the context of methamphetamine exposure, research in rats indicates the miR-30a-3p is up-regulated in the serum exosomes of conditioned place preference models and is associated with vesicular transport and addiction pathways [Xu et al. DOI:10.1007/S10571-023-01323-X]. The stem-loop RT-PCR TaqMan assay provides a specific and sensitive method for quantifying such mature miRNAs, discriminating them from precursors and related sequences with high precision [Chen et al. DOI:10.1093/nar/gni178].