Basic Information

Symbol
hsa-mir-30b
RNA class
miRNA miRNA hairpin
Alias
MIR30B MicroRNA 30b Hsa-MiR-30b-3p Hsa-MiR-30b-5p Hsa-Mir-30b MIRN30B Hsa-Mir-30-P2a_pre MIMAT0004589 MIMAT0000420 MI0000441 Mir-30b
Location (GRCh38)
8:134800520-134800607
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-30b
Sequence length
88 nt
GC content
0.4318

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-36.90 kcal/mol
Thermodynamic ensemble
Free energy: -38.48 kcal/mol
Frequency: 0.0769
Diversity: 5.69
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.(((((,.{(((((...((((((((((.((.((((((({...,........))))))))..))))))))))))...))))))))))).
Forensic Context

A study in humans demonstrated that the mir-30b was downregulated in sepsis patients compared to healthy controls [Li et al. DOI:10.1038/s41598-025-89946-6]. A study in mice and human hematopoietic cells demonstrated that γ-radiation upregulated the mir-30b in serum and cells in a dose-dependent manner, where it directly targeted and inhibited the antiapoptotic factor Mcl-1, promoting apoptosis via the intrinsic pathway [Li et al. DOI:10.1007/s10495-016-1238-1]. In a human study of older monozygotic twins, higher plasma levels of the mir-30b were cross-sectionally associated with decreased functionality in activity of daily living fatigue scores [La Grotta et al. DOI:10.1016/j.mad.2025.112099].