Basic Information

Symbol
hsa-mir-30c-1
RNA class
miRNA miRNA hairpin
Alias
MIR30C1 MicroRNA 30c-1 Hsa-MiR-30c-1-3p Hsa-MiR-30c-5p Hsa-Mir-30c-1 MIRN30C1 Hsa-Mir-30-P2d_pre MIMAT0004674 MIMAT0000244 Mir-30c-1 MI0000736 MiR-30c
Location (GRCh38)
15:70079372-70079468
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-30c-1
Sequence length
89 nt
GC content
0.5056

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.30 kcal/mol
Thermodynamic ensemble
Free energy: -36.07 kcal/mol
Frequency: 0.0570
Diversity: 8.12
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((..((((...(.(((((((.(((...(((((((((....(((...)))))))))))).))).))))))).)...))))))))).
Thermodynamic Ensemble Prediction
.(((((..((((...{.(((((((,(((...(((((((((....,,....,})))))))))),))).))))))).}...))))))))).
Forensic Context

A study in mice demonstrated that the mir-30c-1 was significantly upregulated in a freshwater drowning model compared to both control and saltwater drowning groups, with its expression specifically localized to hippocampal neurons [Yu et al. DOI:10.1016/j.forsciint.2015.06.011]. In a separate study on acute myocardial infarction in mice, the mir-30c-1 was identified among differentially expressed exosomal microRNAs and its mimic significantly reduced hypoxic stress-induced cell death in primary cardiomyocytes and fibroblasts, indicating a potential therapeutic role [Jung et al. DOI:10.3390/biomedicines12020430].