Forensic Context

A study in mice demonstrated that the miR-30c-1-3p was upregulated in freshwater drowning and downregulated in saltwater drowning compared to control in microarray analysis, but quantitative RT-PCR validation showed no statistical difference in its expression between the two drowning groups [Yu et al. DOI:10.1016/j.forsciint.2015.06.011]. In a separate mouse model of acute myocardial infarction, the miR-30c-1-3p was identified among differentially expressed exosomal miRNAs and its mimic significantly reduced hypoxic stress-induced cell death in primary cardiomyocytes and fibroblasts, indicating a potential therapeutic role [Jung et al. DOI:10.3390/biomedicines12020430].