Basic Information

Symbol
hsa-mir-30c-2
RNA class
miRNA miRNA hairpin
Alias
MIR30C2 MicroRNA 30c-2 Hsa-MiR-30c-2-3p Hsa-MiR-30c-5p Hsa-Mir-30c-2 MIRN30C2 Hsa-Mir-30-P2b_pre MIMAT0004550 MIMAT0000244 Mir-30c-2 MI0000254 MiR-30c
Location (GRCh38)
6:71376960-71377031
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden death from CNS diseases Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-30c-2
Sequence length
72 nt
GC content
0.4167

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-25.40 kcal/mol
Thermodynamic ensemble
Free energy: -26.02 kcal/mol
Frequency: 0.3675
Diversity: 1.91
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
{((....(((((((.(((...(((((((((..............))))))))).))).)))))))....))}
Forensic Context

A study in mice demonstrated that the mir-30c-2 is significantly downregulated during all stages of myocardial infarction and exerts anti-apoptotic effects in cardiomyocytes by directly targeting the pro-apoptotic genes Picalm and Skil [Kim et al. DOI:10.1038/s41598-018-33020-x]. In human patients with acute spinal cord injury, plasma levels of the mir-30c-2 were downregulated at emergency room admission and showed a divergent regulatory pattern compared to polytrauma patients without neurotrauma [Hörauf et al. DOI:10.3390/ijms262210954]. A study in mice and human CD34+ hematopoietic cells demonstrated that the mir-30c-2 is upregulated in a radiation dose-dependent manner and directly targets the antiapoptotic factor Mcl-1 via binding to its 3' UTR, promoting apoptosis [Li et al. DOI:10.1007/s10495-016-1238-1].