Basic Information

Symbol
hsa-mir-30d
RNA class
miRNA miRNA hairpin
Alias
MIR30D MicroRNA 30d Hsa-MiR-30d-3p Hsa-MiR-30d-5p Hsa-Mir-30d MIRN30D Hsa-Mir-30-P1a_pre MIMAT0000245 MIMAT0004551 MI0000255 Mir-30d
Location (GRCh38)
8:134804876-134804945
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-30d
Sequence length
70 nt
GC content
0.4571

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-28.10 kcal/mol
Thermodynamic ensemble
Free energy: -29.20 kcal/mol
Frequency: 0.1687
Diversity: 4.09
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in mice demonstrated that the mir-30d is significantly downregulated during all stages of myocardial infarction and exerts anti-apoptotic effects in cardiomyocytes by directly targeting the pro-apoptotic genes Picalm and Skil [Kim et al. DOI:10.1038/s41598-018-33020-x]. In human serum, the mir-30d was found to be downregulated in patients with mild traumatic brain injury at baseline compared to controls, though it was subsequently excluded from further analysis as not suitable for that specific biomarker panel [Polito et al. DOI:10.1007/s11033-020-05386-7].