A study in humans demonstrated that plasma exosomal hsa-miR-1180-3p, identified as a high-abundance diagnostic biomarker, exhibited a downregulated expression pattern from healthy controls to coronary artery disease patients to acute myocardial infarction patients [Guo et al. DOI:10.21037/atm-20-2337]. A study in humans identified the mir-1180-3p as a high-abundance plasma exosomal microRNA with diagnostic potential for acute myocardial infarction, showing a downregulated expression pattern from healthy to coronary artery disease to AMI patient groups [Mei Guo et al. DOI:10.21037/atm-20-2337].