Basic Information

Symbol
hsa-mir-301a
RNA class
miRNA miRNA hairpin
Alias
MIR301A MicroRNA 301a Hsa-MiR-301a-5p Hsa-MiR-301a-3p Hsa-Mir-301a Hsa-Mir-301 MicroRNA 301 MIRN301A MIRN301 Hsa-Mir-130-P2b_pre MIMAT0022696 MIMAT0000688 MI0000745 Mir-301a MIR301
Location (GRCh38)
20:34466325-34466418
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Forensic psychiatry evaluation Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-301a
Sequence length
86 nt
GC content
0.4070

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-30.20 kcal/mol
Thermodynamic ensemble
Free energy: -31.92 kcal/mol
Frequency: 0.0614
Diversity: 9.13
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((..((.(((((.((((.((((((((((.((((........)).)).))))))))))....)))).))))).))..))))).
Thermodynamic Ensemble Prediction
.(((((..((.(((((.((((.,(((((((((.((((,...,}}})..},.)))))))))}....)))).))))).))..))))).
Forensic Context

A study in humans demonstrated that the mir-301a is significantly negatively correlated with age in peripheral blood, with a correlation of -0.530 and a raw P value of 4.00E-08 in a microarray cohort [Meder et al. DOI:10.1373/clinchem.2014.224238]. In a separate human postmortem brain study, the mir-301a was significantly decreased (0.721 of control, p=0.0129) in the prefrontal cortex of depressed suicide subjects compared to non-psychiatric controls [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. A study in humans demonstrated a significant up-regulation of the mir-301a in both plasma (2.3-fold increase) and hippocampal tissue (3.2-fold increase) from a single case of sudden unexpected death in epilepsy (SUDEP) compared to ten control forensic autopsies, supporting its potential as a biomarker for drug-resistant epilepsy and SUDEP risk [De Matteis et al. DOI:10.1016/J.Legalmed.2017.12.003]. A separate review of human postmortem brain studies noted the mir-301a is downregulated in the Brodmann area 9 of subjects with major depressive disorder who died by suicide [Yoshino & Dwivedi DOI:10.3389/fpsyt.2020.543893].