Basic Information

Symbol
hsa-mir-302c
RNA class
miRNA miRNA hairpin
Alias
MIR302C MicroRNA 302c Hsa-MiR-302c-5p Hsa-MiR-302c-3p Hsa-Mir-302c MIRN302C Hsa-Mir-430-P2_pre MIMAT0000716 MIMAT0000717 MI0000773 Mir-302c
Location (GRCh38)
4:112648363-112648430
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-302c
Sequence length
68 nt
GC content
0.4559

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-31.30 kcal/mol
Thermodynamic ensemble
Free energy: -31.82 kcal/mol
Frequency: 0.4292
Diversity: 2.64
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
((((((((..(((((((((((((.((((.(({...)))..)))).)))))))))))))..))))))))
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with the mir-302c being downregulated in hypertrophic scar tissue compared to normal tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in human ex vivo skin explants demonstrated that the mir-302c was among 37 preselected miRNAs analyzed by qPCR in exosome-like vesicle-enriched dermal interstitial fluid fractions, but it could not be detected in this compartment [Foessl et al. DOI:10.3390/ijms22179209]. A separate review noted that in other biological contexts, such as mouse and human spermatozoa, a circular RNA named circNAPEPLDiso1 specifically interacts with the mir-302c among other miRNAs, suggesting a potential role as a paternal-derived sponge inside fertilized oocytes [Di Agostino et al. DOI:10.3389/fcell.2020.00389].