Basic Information

Symbol
hsa-mir-3074
RNA class
miRNA miRNA hairpin
Alias
MIR3074 MicroRNA 3074 Hsa-Mir-3074 Hsa-MiR-3074-3p Hsa-MiR-3074-5p MIMAT0015027 MIMAT0019208 MI0014181 Mir-3074
Location (GRCh38)
9:95086014-95086094
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-3074
Sequence length
81 nt
GC content
0.5432

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.00 kcal/mol
Thermodynamic ensemble
Free energy: -35.55 kcal/mol
Frequency: 0.4086
Diversity: 2.20
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.((((.((.((((((((.((((..((((.............))))...)))).)))))))).)).))))..)))))
Thermodynamic Ensemble Prediction
(((((.((((.((.((((((((.((((..((((.............))))...)))).)))))))).)).))))..)))))
Forensic Context

A study in humans demonstrated that the mir-3074-5p was significantly upregulated in the plasma of patients with coronary artery disease compared to normal coronary artery controls, as identified through RNA sequencing [Zhong et al. DOI:10.1002/jcla.23020]. A study in humans and mice demonstrated that the mir-3074-5p is downregulated in the peripheral blood of antidepressant responders to duloxetine and placebo in a discovery cohort, but this finding was not significant in a first replication cohort, and it was not included in further analyses [Lopez et al. DOI:10.1038/ncomms15497].