Forensic Context

A review of human studies identified the miR-31-5p as upregulated in burn hypertrophic scar tissue compared to normal skin and in venous ulcers versus normal skin and acute wounds [Siu et al. DOI:10.1111/wrr.13100]. Further research in human and rodent models demonstrates that exosomal the miR-31-5p from adipose-derived stem cells targets FGF4, and its suppression enhances angiogenesis, migration, and proliferation in high glucose-induced HUVECs and accelerates diabetic wound healing in mice [Wang et al. DOI:10.1007/s00438-024-02183-w].