Basic Information

Symbol
hsa-mir-3126
RNA class
miRNA miRNA hairpin
Alias
MIR3126 MicroRNA 3126 Hsa-Mir-3126 Hsa-Mir-3126_pre Hsa-MiR-3126-5p Hsa-MiR-3126-3p MIMAT0014989 MIMAT0015377 MI0014143 Mir-3126
Location (GRCh38)
2:69103682-69103755
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Individual identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-3126
Sequence length
74 nt
GC content
0.4054

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-27.10 kcal/mol
Thermodynamic ensemble
Free energy: -28.76 kcal/mol
Frequency: 0.0674
Diversity: 4.16
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((.((...(((.(((((((((.(((............))).))))))))).)))...)).))))))))
Thermodynamic Ensemble Prediction
{(((((((.((...(((.(((((((((.(((............))).))))))))).))).}.)).)))))))}
Forensic Context

A study in humans identified the mir-3126-5p as a pro-fibrotic microRNA present in exosomes from the pericardial fluid of atrial fibrillation patients, where it was reported to drive cardiac fibrosis [Silva et al. DOI:10.3390/ijms25158329]. In a separate forensic investigation in humans, the mir-3126-5p was found to be differentially expressed and shared across three pairs of monozygotic twins, indicating its potential as a biomarker for distinguishing genetically identical individuals [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].