A study in humans demonstrated that plasma exosomal hsa-miR-3127-3p was upregulated in the coronary artery disease group compared with the acute myocardial infarction group and was part of an 18-miRNA panel with a diagnostic area under the curve of 0.75 for coronary artery disease [Guo et al. DOI:10.21037/atm-20-2337].