Basic Information
Symbol
hsa-miR-3135a
RNA class
miRNA
mature miRNA
Alias
hsa-miR-3135a
MIR3135A
MicroRNA 3135a
Location (GRCh38)
-
Forensic tag(s)
Sudden cardiac death diagnosis
Drug abuse diagnoses
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.80 kcal/mol
Thermodynamic ensemble
Free energy:
-34.99 kcal/mol
Frequency:
0.7530
Diversity:
2.42
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((.((.(((((((..(((.(((((((((.((.......))))))))))).))).....)))))))))))))))
Thermodynamic Ensemble Prediction
{(((({{((.(((((((.,(((.(((((((((.((.......)}))))))))).))),....))))))))))))))}
Forensic Context
A study in humans identified the miR-3135a as a top upregulated circulating microRNA in patients with acute myocardial infarction compared to non-AMI controls, validated by qRT-PCR [Zhong et al. DOI:10.1002/jcla.23099]. In a separate human study, the miR-3135a was found to be upregulated in ethanol-exposed human embryonic stem cell-derived cortical interneurons, indicating its involvement in alcohol-induced transcriptomic changes [Lim et al. DOI:10.1038/s41398-021-01635-w].