Basic Information

Symbol
hsa-mir-320b-1
RNA class
miRNA miRNA hairpin
Alias
MIR320B1 MicroRNA 320b-1 Hsa-Mir-320b-1 Hsa-MiR-320b MIRN320B1 Hsa-Mir-320-P2a_pre MIMAT0005792 Mir-320b-1 MIR320B-1 MI0003776 hsa-mir-320b
Location (GRCh38)
17:81125877-81125955
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-320b-1
Sequence length
72 nt
GC content
0.3750

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-26.30 kcal/mol
Thermodynamic ensemble
Free energy: -26.78 kcal/mol
Frequency: 0.4563
Diversity: 2.44
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in humans identified the mir-320b-1 as a differentially expressed miRNA that was upregulated in sepsis patients compared to healthy controls [Qin et al. DOI:10.1097/JCMA.0000000000000209]. A systematic review of human studies found the mir-320b-1 is associated with multiple environmental exposures, showing a positive association with traffic-related air pollution intensity in plasma, a negative association with specific metals in plasma from coke oven workers, and significant associations with persistent organic pollutant exposure in buffy coats and with polycyclic aromatic hydrocarbon metabolites in plasma [Kotsyfakis et al. DOI:10.1080/1354750X.2019.1652348]. A study in humans with alcohol use disorders identified the mir-320b-1 as a serum microRNA biomarker significantly increased by 137.1% in AUD subjects compared to controls [Ignacio et al. DOI:10.1186/S12868-015-0195-X]. This finding was validated in cross-species paradigms, and a review of RNA biomarkers for AUD confirmed the mir-320b-1 is upregulated in AUD serum [Ferguson et al. DOI:10.3389/Fnmol.2022.1032362].