Forensic Context

A study in humans identified the mir-320b-2 as significantly upregulated in the peripheral blood of sepsis patients compared to healthy controls [Qin et al. DOI:10.1097/JCMA.0000000000000209]. In a separate human study investigating myocardial infarction, the mir-320b-2 was noted in the literature as having decreased plasma levels in MI patients from a previous study in Chinese populations, though it was not directly studied in the current experimental cohort [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. A systematic review of human studies found that the mir-320b-2 is significantly associated with multiple environmental exposures, including traffic-related air pollution (TRAP) in plasma [Kotsyfakis et al. DOI:10.1080/1354750X.2019.1652348], metal and PAH co-exposure in plasma of coke oven workers [Kotsyfakis et al. DOI:10.1080/1354750X.2019.1652348], and persistent organic pollutant (POP) exposure in buffy coats [Kotsyfakis et al. DOI:10.1080/1354750X.2019.1652348]. In a separate human study, serum levels of the mir-320b-2 were increased by 142.9% in subjects with alcohol use disorders (AUDs) and cross-species validation in rat and mouse models confirmed its role in pathways affecting cell proliferation and cell death [Ignacio et al. DOI:10.1186/S12868-015-0195-X].