Basic Information

Symbol
hsa-miR-325
RNA class
miRNA mature miRNA
Alias
hsa-miR-325 MIR325 MicroRNA 325
Location (GRCh38)
-
Forensic tag(s)
Wound age identification Sudden cardiac death diagnosis Drug abuse diagnoses
External database
miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-miR-325
Sequence length
23 nt
GC content
0.4783

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.60 kcal/mol
Thermodynamic ensemble
Free energy: -34.34 kcal/mol
Frequency: 0.0594
Diversity: 10.97
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((((((((((..(((.((((.(.(((((((((((...))))).......)))))).).)))).)))..))))))))))))))...........
Thermodynamic Ensemble Prediction
.((((((((((((((..(((.((((.(.((((((({({(...,}}}}.,....})))))).).)))).)))..)))))))))))))){{,,...,,},
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns in human skin tissue and cells post-burn and in hypertrophic scar tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the miR-325 was identified as a biomarker of acute myocardial ischemia (AMI) via LASSO regression, with the panel of key miRNAs achieving an area under the curve (AUC) of 75% in ROC analysis [Zhao et al. DOI: 10.3390/cimb47110889]. In a separate investigation in rats, the miR-325 was found to be downregulated in the infralimbic prefrontal cortex after a 4-week abstinence from escalated cocaine intake [Kumaresan et al. DOI: 10.3390/Biomedicines11051368].