Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with the let-7c being downregulated in deep partial thickness burn skin four days post-burn compared to normal skin and also downregulated in heat-shocked fibroblasts and in skin wounds [Siu et al. DOI:10.1111/wrr.13100]. In a separate human astrocyte model, extracellular vesicle-derived hsa-let-7c-5p was significantly downregulated after 3 Gy proton radiation exposure and targets genes associated with cognitive delay and epileptic encephalopathy [Deriesha Gaines et al. DOI:10.1016/j.lssr.2021.11.001].