Basic Information

Symbol
hsa-mir-122
RNA class
miRNA miRNA hairpin
Alias
MIR122 MicroRNA 122 Hsa-MiR-122-5p Hsa-MiR-122-3p Hsa-Mir-122a Hsa-Mir-122 MiR-122 MicroRNA 122a MIRN122A MIRN122 Hsa-Mir-122_pre MIMAT0000421 MIMAT0004590 MiRNA122A MI0000442 MiRNA122 MIR122A hsa-mir-122a
Location (GRCh38)
18:58451074-58451158
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mixture deconvolution Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-122
Sequence length
85 nt
GC content
0.4353

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-45.70 kcal/mol
Thermodynamic ensemble
Free energy: -46.41 kcal/mol
Frequency: 0.3152
Diversity: 3.42
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in human forensic samples demonstrated that hsa-miR-122-5p exhibits pronounced separation properties for liver tissue identification, with no expression overlap in individual native samples except for one potential outlier lung swab, achieving 100% correct classification in native samples and 96% in dried swabs during validation [Sauer et al. DOI:10.1016/j.fsigen.2017.02.002]. The method was successfully applied to realistic forensic samples including mixtures, aged material, and mock casework samples from experimental shootings and stabbings, where liver was correctly identified even as a minor component in mixtures. A study in mice demonstrated that the mir-122 serves as a biomarker for postmortem interval (PMI) estimation beyond five days in liver tissue [Lei et al. DOI:10.1093/gpbjnl/qzag007].