Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns in human skin tissue and cells post-burn and in hypertrophic scar tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that miR-339-3p is upregulated in postischemic left ventricular myocardium following cardiac surgery with cardiopulmonary bypass, showing a 2.62-fold increase [Saddic et al. DOI:10.1152/physiolgenomics.00049.2015]. Research in mice indicated that miR-339-3p is upregulated in primary microglial cells and inhibits alcohol-induced brain inflammation by regulating the NF-κB pathway [Mayfield DOI:10.1016/J.Alcohol.2017.01.004].