Forensic Context

A study in humans demonstrated that hsa-miR-34a-5p was upregulated in plasma from patients with acute spinal cord injury at emergency room admission compared to healthy controls using next-generation sequencing, though this differential expression was not significant in subsequent droplet digital PCR validation [Hörauf et al. DOI:10.3390/ijms262210954]. In a separate human study, the miR-34a-5p was identified as upregulated in the peripheral whole blood of sepsis patients compared to healthy controls through RNA-sequencing analysis [Qin et al. DOI:10.1097/JCMA.0000000000000209]. A study in humans identified the miR-34a-5p as a potential biomarker for the 12- and 24-month periods of atrial fibrillation, where it was upregulated and its target genes were enriched in cancer-related pathways, focal adhesion, and adherens junctions [Wang et al. DOI:10.1016/j.hrtlng.2020.03.021].