Basic Information

Symbol
hsa-mir-34b
RNA class
miRNA miRNA hairpin
Alias
MIR34B MicroRNA 34b Hsa-MiR-34b-3p Hsa-MiR-34b-5p Hsa-Mir-34b MIRN34B Hsa-Mir-34-P2a_pre MIMAT0004676 MIMAT0000685 MI0000742 MiRNA34B Mir-34b
Location (GRCh38)
10:51299573-51299655
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-34b
Sequence length
84 nt
GC content
0.4643

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.80 kcal/mol
Thermodynamic ensemble
Free energy: -34.28 kcal/mol
Frequency: 0.0908
Diversity: 5.93
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((((..(((({..(((((((...((((.((((((((((.....)),})))))))))))...)))))))..},))))..)))))
Forensic Context

A study in humans demonstrated that the mir-34b was significantly decreased in the prefrontal cortex of depressed suicide subjects compared to non-psychiatric controls, with its expression measured at 0.672 of control levels [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. A study in mice demonstrated that the mir-34b was differentially expressed in blood 24 hours after γ-irradiation [Jia & Wang DOI:10.3389/fcell.2022.861451]. In human studies, the mir-34b was downregulated in testicular biopsies of azoospermia patients and in subfertile men, showing high diagnostic value with an AUC of 0.944 and 0.852, respectively [Ahmed S. Doghish et al. DOI:10.1007/s00210-024-03594-7].