Forensic Context

A study in humans demonstrated that the miR-34b-3p was upregulated in venous ulcers compared to normal skin and acute wounds [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that early plasma levels of miR-34b-3p predicted survival after whole thorax irradiation with high accuracy, where elevated expression at day 2 was associated with reduced survival in C57Bl/6 mice and was linked to TGF-β/SMAD signaling pathways [Rogers et al. DOI:10.1371/journal.pone.0232411]. In rats, miR-34b-3p was upregulated 1.99-fold in the ventral tegmental area of heroin-addicted animals, indicating its alteration in brain regions associated with substance abuse [Pence et al. DOI:10.1007/S00221-024-06972-Y].