Basic Information

Symbol
hsa-mir-34c
RNA class
miRNA miRNA hairpin
Alias
MIR34C MicroRNA 34c Hsa-MiR-34c-5p Hsa-MiR-34c-3p Hsa-Mir-34c MIRN34C Hsa-Mir-34-P2b_pre MIMAT0004677 MIMAT0000686 MI0000743 MiRNA34C Mir-34c
Location (GRCh38)
11:111513439-111513515
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-34c
Sequence length
77 nt
GC content
0.4026

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-28.00 kcal/mol
Thermodynamic ensemble
Free energy: -28.99 kcal/mol
Frequency: 0.2013
Diversity: 2.73
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((..(((((.(((.((((.(((((.((((((.((....)).))))))))))).)))).))).)))))..)))).
Thermodynamic Ensemble Prediction
,((((..(((((.(((.((((.(((((.((((((.({....}).))))))))))).)))).))).)))))..)))),
Forensic Context

A study in humans demonstrated that the mir-34c was significantly decreased in the prefrontal cortex of depressed suicide subjects compared to non-psychiatric controls [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. A study in mice demonstrated that the mir-34c was upregulated in liver tissue following whole-body ionizing radiation exposure, with a log2 fold change of 1.62 [Lu et al. DOI:10.1002/cbin.10627]. In human male infertility research, the mir-34c was downregulated in semen and testicular biopsies of azoospermia patients and was identified as a diagnostic biomarker with AUC values ranging from 0.751 to 0.978 [Doghish et al. DOI:10.1007/s00210-024-03594-7].