Forensic Context

A study in human forensic samples demonstrated that miR-122-3p exhibited pronounced separation properties for liver tissue identification, with no expression overlap in individual native samples except for one potential outlier lung swab, achieving 100% correct classification in native samples and 96% in dried swabs during validation [Sauer et al. DOI:10.1016/j.fsigen.2017.02.002]. A study in mice demonstrated that the miR-122-3p is a highly expressed, liver-specific miRNA [Lu et al. DOI:10.1002/cbin.10627]. In a model of methanol poisoning, the miR-122-3p was downregulated in the ocular tissue of male mice at all time points following a 4 g/kg dose [Gunay et al. DOI:10.1016/J.Fct.2023.113666].