Forensic Context

A study in humans demonstrated that the miR-34c-5p was significantly decreased in the prefrontal cortex of depressed suicide subjects compared to non-psychiatric controls [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. In a separate review of human skin conditions, the miR-34c-5p was reported as upregulated in venous ulcers compared to normal skin and acute wounds [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the miR-34c-5p was significantly downregulated in myocardial tissue following acute myocardial infarction and was computationally predicted to target heart rate-related genes Cacna1e and Ank2 [Tuerxun et al. DOI:10.1007/s12013-024-01528-x]. In a separate investigation in rats, plasma exosomal levels of the miR-34c-5p were found to decrease significantly over time after AMI onset, identifying it among key temporally dynamic biomarkers [Zhou et al. DOI:10.007/s00414-025-03583-2].