Basic Information

Symbol
hsa-mir-342
RNA class
miRNA miRNA hairpin
Alias
MIR342 MicroRNA 342 Hsa-MiR-342-3p Hsa-MiR-342-5p Hsa-Mir-342 MIRN342 Hsa-Mir-342_pre MIMAT0000753 MIMAT0004694 MI0000805
Location (GRCh38)
14:100109655-100109753
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-342
Sequence length
99 nt
GC content
0.4949

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-47.70 kcal/mol
Thermodynamic ensemble
Free energy: -49.36 kcal/mol
Frequency: 0.0675
Diversity: 10.37
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....(((((.((((((((.((((((..((((((..(((((.((((.....)))....).)))))))))))....)))))).)))))))))))))....
Thermodynamic Ensemble Prediction
.....(((((.((((((((.((((((..((((((..{({((,((({.....,,}....),))))}))))))....)))))).)))))))))))))....
Forensic Context

A study in humans demonstrated that hsa-miR-342-5p was upregulated in septic shock patients compared to healthy controls and was highlighted for a crucial role in septic shock [Li et al. DOI:10.1038/s41598-025-89946-6]. A study in mice demonstrated that the mir-342 was upregulated in plasma following hindlimb irradiation and was part of an eight-microRNA signature that could segregate animals by local radiation injury severity, with the mir-342 specifically influencing the separation of the high-dose (80 Gy) group and showing a positive correlation with injury severity [Ancel et al. DOI:10.1038/s41598-024-52258-2]. In a human forensic autopsy case, the expression of the mir-342 was measured in plasma and hippocampal tissue from a sudden unexpected death in epilepsy (SUDEP) case compared to control cases, though no significant expression differences were found for this specific miRNA in that context [De Matteis et al. DOI:10.1016/J.Legalmed.2017.12.003].