Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns in human skin tissue and cells post-burn and in hypertrophic scar tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that miR-342-3p in peripheral blood leukocytes is a radiation-sensitive miRNA, showing a negative correlation with the logarithm of radiation dose at 48 hours post-irradiation and exhibiting the highest correlation in validation [Li et al. DOI:10.1177/15593258221123679]. In a separate mouse model of localized radiation injury, plasma miR-342-3p was upregulated and formed part of an eight-miRNA signature capable of segregating injury severity, showing a positive correlation with injury severity and influencing the separation of the highest dose group [Ancel et al. DOI:10.1038/s41598-024-52258-2].