Forensic Context

A study in human forensic samples demonstrated that hsa-miR-122-5p exhibits pronounced separation properties for liver tissue identification, with no overlap between liver and non-target tissues in individual native samples except for one potential outlier lung swab, achieving 100% correct classification in native samples and 96% in dried swabs during validation using Binary Logistic Regression [Sauer et al. DOI:10.1016/j.fsigen.2017.02.002]. A study in mice demonstrated that the miR-122-5p aggravates ionizing radiation-induced rectal injury by targeting CCAR1, and its antagomir mitigated this injury [Jia et al. DOI:10.3389/fcell.2022.861451].