Basic Information

Symbol
hsa-mir-122b
RNA class
miRNA miRNA hairpin
Alias
MIR3591 MicroRNA 3591 Hsa-Mir-3591 Hsa-Mir-122b Hsa-MiR-122b-5p Hsa-MiR-122b-3p MIMAT0019876 MIMAT0019877 MI0017383 hsa-mir-3591
Location (GRCh38)
3:160404588-160404685
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-122b
Sequence length
73 nt
GC content
0.4110

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-30.60 kcal/mol
Thermodynamic ensemble
Free energy: -31.45 kcal/mol
Frequency: 0.2530
Diversity: 2.12
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in human aortic endothelial cells demonstrated that the mir-122b-3p was induced at 72 hours following a 10 Gy X-ray dose, with its target mRNAs such as NEK7 being repressed [Chopra et al. DOI:10.1038/s41598-022-24051-6]. In a separate human clinical study, the mir-122b-3p was identified as differentially expressed and downregulated in patients with sepsis compared to those with septic shock [Li et al. DOI:10.1038/s41598-025-89946-6].