Forensic Context

A study in humans demonstrated that the miR-361-3p was more abundant in circulating T cells during the injury stage compared to the recovery stage in major trauma patients according to next-generation sequencing, though it was not significantly upregulated in subsequent RT-qPCR validation [Rau et al. DOI:10.2147/JIR.S375881]. A study in humans demonstrated that the miR-361-3p was significantly up-regulated in the serum of patients with obstructive sleep apnea syndrome (OSAS) compared to healthy controls and was part of a four-miRNA diagnostic panel achieving an AUC of 0.955 [Mo et al. DOI:10.2147/NSS.S382765]. In rats, research showed that the miR-361-3p was significantly up-regulated in plasma exosomes 24 hours after traumatic brain injury (TBI), identifying it as a potential diagnostic biomarker [Wang et al. DOI:10.7150/ijms.39667].