Basic Information

Symbol
hsa-mir-3614
RNA class
miRNA miRNA hairpin
Alias
MIR3614 MicroRNA 3614 Hsa-MiR-3614-5p Hsa-Mir-3614 Hsa-MiR-3614-3p MIMAT0017992 MIMAT0017993 MI0016004 Mir-3614
Location (GRCh38)
17:56891270-56891355
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden unexpected death diagnosis Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-3614
Sequence length
86 nt
GC content
0.5000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.30 kcal/mol
Thermodynamic ensemble
Free energy: -44.60 kcal/mol
Frequency: 0.6188
Diversity: 2.50
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((((......)))))(((.((((((((((((((((((..........)))))))))))))))))).)))................
Forensic Context

A study in humans demonstrated that the insertion allele of the mir-3614-5p within the 3'UTR of the RYR2 gene is significantly associated with an increased risk of Sudden Unexplained Death (OR=2.03) and leads to higher RYR2 expression at mRNA and protein levels in myocardium, with in-silico prediction suggesting this polymorphism could alter local mRNA structure and potentially disrupt hsa-miR-3614-5p binding [Wang et al. DOI:10.1016/J.Forsciint.2016.12.005]. A separate review of human studies reported that hsa-miR-3614-5p is upregulated six hours post-burn in heat-shocked skin epidermal stem cells compared to controls [Siu et al. DOI:10.1111/wrr.13100].