A study in humans demonstrated that plasma exosomal hsa-miR-3615, identified as a high-abundance miRNA, exhibited a downregulated expression pattern from healthy controls to coronary artery disease patients to acute myocardial infarction patients, and was part of an 18-miRNA panel that achieved an area under the curve of 0.87 for diagnosing acute myocardial infarction [Guo et al. DOI:10.21037/atm-20-2337]. A study in humans with alcohol use disorders demonstrated that the mir-3615 was increased by 56.4% in serum and was identified as a Tier B biomarker of AUD [Ignacio et al. DOI:10.1186/S12868-015-0195-X].