Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific dysregulation patterns observed in human skin tissue samples and cell lines post-burn and in hypertrophic scar tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that miRNA expression profiles can distinguish monozygotic twins, with 545 miRNAs differentially expressed across seven twin pairs, and validation by qRT-PCR confirmed differential expression for select miRNAs including the mir-3616-3p [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003].