Basic Information

Symbol
hsa-mir-362
RNA class
miRNA miRNA hairpin
Alias
MIR362 MicroRNA 362 Hsa-MiR-362-3p Hsa-MiR-362-5p Hsa-Mir-362 MIRN362 Hsa-Mir-362-P1_pre MIMAT0000705 MIMAT0004683 MI0000762 Mir-362
Location (GRCh38)
16:69933081-69933180
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-362
Sequence length
65 nt
GC content
0.4154

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-31.50 kcal/mol
Thermodynamic ensemble
Free energy: -31.97 kcal/mol
Frequency: 0.4687
Diversity: 4.25
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in humans demonstrated that the mir-362 was significantly upregulated in serum from patients with mild traumatic brain injury (mTBI) at baseline compared to controls, with expression progressively reducing at 24 and 48 hours post-injury, and it was also differentially expressed between mTBI patients and those with other injuries, identifying it as a sensitive and specific biomarker for monitoring the post-trauma period [Polito et al. DOI:10.1007/s11033-020-05386-7]. In a separate pilot study using a Göttingen minipig model of lethal total body irradiation, the mir-362 was identified as an early marker, being consistently down-regulated in plasma across all post-irradiation phases [Chakraborty et al. DOI:10.1038/s41598-023-45250-9].