Forensic Context

A study in humans demonstrated that the miR-362-5p was significantly upregulated in serum from patients with mild traumatic brain injury at baseline compared to controls, with expression progressively reducing at 24 and 48 hours post-injury, establishing it as a sensitive and specific biomarker for monitoring the post-trauma period [Polito et al. DOI:10.1007/s11033-020-05386-7]. A study in mice demonstrated that the miR-362-5p was down-regulated in splenic monocytes from burn-injured animals relative to sham controls according to microarray analysis [Liu et al. DOI:10.1111/iwj.14288]. In a separate human study, the miR-362-5p was identified as down-regulated in the peripheral blood of sepsis patients compared to healthy controls via microarray, though its expression trend differed in subsequent RT-qPCR validation [Xu et al. DOI:10.3892/mmr.2022.12850].