Basic Information

Symbol
hsa-mir-1224
RNA class
miRNA miRNA hairpin
Alias
MIR1224 MicroRNA 1224 Hsa-MiR-1224-3p Hsa-MiR-1224-5p Hsa-Mir-1224 MIRN1224 MIMAT0005459 MIMAT0005458 MI0003764 Mir-1224
Location (GRCh38)
8:128049152-128049238
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1224
Sequence length
85 nt
GC content
0.7059

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.10 kcal/mol
Thermodynamic ensemble
Free energy: -45.19 kcal/mol
Frequency: 0.1697
Diversity: 18.25
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((...(((((((((..((((....))))((((..((((((((...))))..))))..)))))))))))))...)))))).
Thermodynamic Ensemble Prediction
.((((((...(((((((((.{((,({,.,|}}}{{{|,,((((((((...)))).,))}}..)))})))))))))...)))))).
Forensic Context

A study in humans demonstrated that the mir-1224 was upregulated 11.19-fold in denatured dermis from deep burn patients compared to paired normal skin [Liang et al. DOI:10.1016/j.burns.2011.10.014]. A subsequent review confirmed its upregulation 4 days post-burn in deep partial thickness burn skin and noted its dysregulation in burn hypertrophic scar tissue, with expression patterns varying between studies [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-1224 in urine could be used as an early radiation-responsive marker of radiation nephropathy [Jia et al. DOI:10.3389/fcell.2022.861451]. In a separate investigation across three inbred mouse strains (C3H/HeJ, BALB/c, and C57BL/6), the mir-1224 was identified as an important miRNA in decision tree models for classifying low versus high radiation dose at day 7 and for classifying viable versus high-risk subjects at day 1 post-irradiation [Martello et al. DOI:10.1667/RADE-23-00007.1].