A study in humans demonstrated that the miR-3663-3p was significantly upregulated in the peripheral blood of patients with sepsis compared to healthy controls and showed a positive correlation with proinflammatory cytokine levels (IL-6, IL-21, CXCL8, MCP-1) and TDAG8/TLR4 mRNA expression [Xu et al. DOI:10.3892/mmr.2022.12850].