Basic Information

Symbol
hsa-mir-370
RNA class
miRNA miRNA hairpin
Alias
MIR370 MicroRNA 370 Hsa-Mir-370 Hsa-MiR-370-3p MIRN370 Hsa-Mir-370_pre Hsa-MiR-370-5p MIMAT0026483 MIMAT0000722 MI0000778 Mir-370
Location (GRCh38)
14:100911139-100911213
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-370
Sequence length
75 nt
GC content
0.5733

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-31.60 kcal/mol
Thermodynamic ensemble
Free energy: -33.13 kcal/mol
Frequency: 0.0837
Diversity: 7.38
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((....(((((((..((((((.((((...(((.........))).)))).))))))..)))))))))))))
Thermodynamic Ensemble Prediction
((((((,...{((((((..((((((.((((.,,(,{.........))).)))).))))))..)))))))))))))
Forensic Context

A study in humans identified the mir-370 as increased in patients with unstable angina pectoris and acute pulmonary embolism [Tong et al. DOI:10.3390/ijms19051467]. A study in human blood demonstrated that the mir-370 level was significantly increased in coronary artery disease patients with hyperlipidaemia, indicating its potential role in cause of death determination for sudden cardiac death [Li et al. DOI:10.1093/fsr/owad003]. In a separate investigation of human prefrontal cortex, the mir-370 was found to be down-regulated in subjects with bipolar disorder [Smalheiser et al. DOI:10.1371/journal.pone.0086469].