Basic Information

Symbol
hsa-mir-373
RNA class
miRNA miRNA hairpin
Alias
MIR373 MicroRNA 373 Hsa-MiR-373-3p Hsa-MiR-373-5p Hsa-Mir-373 MIRN373 Hsa-Mir-430-P7_pre MIMAT0000725 MIMAT0000726 MI0000781 MiRNA373 Mir-373
Location (GRCh38)
19:53788705-53788773
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-373
Sequence length
69 nt
GC content
0.5072

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-36.40 kcal/mol
Thermodynamic ensemble
Free energy: -37.56 kcal/mol
Frequency: 0.1518
Diversity: 3.63
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in humans analyzing peripheral blood mononuclear cells from coronary artery disease (CAD) patients identified a comprehensive ceRNA regulatory network and validated five key miRNAs, including the mir-373 which was found to be upregulated in CAD with an expression 2.70 times higher than in controls [He et al. DOI:10.1155/2021/6658115]. A review of the literature indicates that the mir-373 is a hypoxamir potently induced by hypoxia in a HIF-1α-dependent manner in mammalian cells, where it targets the RAD23B transcript to inhibit DNA repair [Nallamshetty et al. DOI:10.1016/j.freeradbiomed.2013.05.022]. In the forensic pathology context of human asphyxia deaths, the mir-373 is identified as a diagnostic biomarker that is upregulated in lung tissue, with its function linked to the inhibition of DNA repair as part of the acute hypoxic response [Scopetti et al. DOI:10.7150/ijms.79539].