Basic Information

Symbol
hsa-mir-374a
RNA class
miRNA miRNA hairpin
Alias
MIR374A MicroRNA 374a Hsa-MiR-374a-3p Hsa-MiR-374a-5p Hsa-Mir-374a Hsa-Mir-374 MicroRNA 374 MIRN374A MIRN374 Hsa-Mir-374-P1_pre MIMAT0000727 MIMAT0004688 MI0000782 Mir-374a
Location (GRCh38)
X:74287286-74287357
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Chronological age estimation Sudden death from CNS diseases
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-374a
Sequence length
72 nt
GC content
0.3194

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.50 kcal/mol
Thermodynamic ensemble
Free energy: -34.98 kcal/mol
Frequency: 0.4614
Diversity: 1.57
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((((.(((.((((((((((((.(((((((((((....))))))))))).)))))))))))).))).))))}
Forensic Context

A study in humans demonstrated that the mir-374a is significantly decreased in the plasma of male acute myocardial infarction patients compared to healthy controls, as identified by next-generation sequencing and validated by RT-qPCR, representing its first reported association with this condition [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. In a separate investigation of physiologically unaffected human individuals, the mir-374a was found to be significantly negatively correlated with age in peripheral whole blood [Meder et al. DOI:10.1373/clinchem.2014.224238]. A study in human newborns demonstrated that the mir-374a is downregulated in umbilical cord blood of newborns with hypoxic-ischemic encephalopathy, indicating its role as a biomarker for hypoxic events [Lai et al. DOI:10.1016/j.pedneo.2024.05.002].