Basic Information

Symbol
hsa-mir-374b
RNA class
miRNA miRNA hairpin
Alias
MIR374B MicroRNA 374b Hsa-MiR-374b-3p Hsa-MiR-374b-5p Hsa-Mir-374b MIRN374B Hsa-Mir-374-P2_pre MIMAT0004956 MIMAT0004955 MI0005566 Mir-374b
Location (GRCh38)
14:101031987-101032064
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-374b
Sequence length
72 nt
GC content
0.4167

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-40.30 kcal/mol
Thermodynamic ensemble
Free energy: -41.18 kcal/mol
Frequency: 0.2400
Diversity: 4.15
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((.(((((((..(((((((((((((((((((((....)))))))))))))))))))))..))))))).))..
Thermodynamic Ensemble Prediction
{(.(((((((..(((((((((((((((((((((....)))))))))))))))))))))..))))))).))..
Forensic Context

A study in Göttingen minipigs (Sus scrofa domestica) demonstrated that the mir-374b was consistently down-regulated across all post-lethal total body irradiation phases, identifying it as an early marker of radiation exposure [Chakraborty et al. DOI:10.1038/s41598-023-45250-9]. In human male infertility research, the mir-374b (miR-374b) was found to be down-regulated in the seminal plasma of azoospermia patients and up-regulated in asthenozoospermia patients, showing diagnostic potential with AUC values of 0.839 and 0.813, respectively [Doghish et al. DOI:10.1007/s00210-024-03594-7].