Basic Information

Symbol
hsa-mir-375
RNA class
miRNA miRNA hairpin
Alias
MIR375 MicroRNA 375 Hsa-Mir-375 Hsa-MiR-375 MIRN375 Hsa-Mir-375_pre Hsa-MiR-375-5p Hsa-MiR-375-3p MIMAT0037313 MIMAT0000728 MI0000783 MiRNA375 Mir-375
Location (GRCh38)
2:219001645-219001708
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-375
Sequence length
64 nt
GC content
0.6719

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-26.80 kcal/mol
Thermodynamic ensemble
Free energy: -27.34 kcal/mol
Frequency: 0.4163
Diversity: 2.81
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
,({((((.((((((...((.(((((.((........)).))))).))...)))))))))).)).
Forensic Context

A study in humans demonstrated that the mir-375 is significantly decreased in the plasma of acute myocardial infarction (MI) patients compared to healthy controls, with this novel association validated by next-generation sequencing and RT-qPCR, showing a fold change of -2.1 and an AUC of 0.87 for diagnostic accuracy [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. Another human study in young acute coronary syndrome patients identified the mir-375 as down-regulated via small RNA sequencing in ST-elevation MI, though this specific finding was not significant in subsequent qRT-PCR validation [Tong et al. DOI:10.3390/ijms19051467].